Research Interests

Biomedical engineering; drug delivery; cancer targetting; tissue engineering; biomaterial; polymer and peptide design. Drug delivery; cancer targeting; tissue engineering; biomaterial; polymer and peptide design.

Current Research Activities:

Biomedical engineering; drug delivery; cancer targeting; tissue engineering; biomaterial; polymer and peptide design.

Selected Publications and Patents

Li, Qianqian, Chau, Ying (2010) "Neural differentiation directed by self-assembling peptide scaffolds presenting laminin-derived epitopes", Journal of Biomaterial Research Part A

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Wang, Weiping, Chau, Ying (2009) "Self-assembled peptide nanorods as building blocks of fractal patterns", Soft Matter, 5(24): 4893-4898.

Li, Zhongyu, Chau, Ying (2009) "Synthesis of linear polyether polyol derivatives as new materials for bioconjugation", Bioconjugate Chemistry, 20(4):780-789.

Zhong, Jeiying, Chau, Ying (2008) "Antitumor activity of a membrane lytic peptide cyclized with a linker sensitive to membrane type 1-matrix metalloproteinase", Molecular Cancer Therapeutics, 7(9):2933-40.

Wang, Weiping, Yang, Zhimou, Patanavanich, Siamrut, Xu, Bing, Chau, Ying (2008) "Controlling Self-assembly within Nanospace for Peptide Nanoparticle Fabrication", Soft Matter, DOI: 10.1039/b801890a.

Chau, Ying, Luo, Ying, Cheung, Alex, Nagai, Yusuke, Zhang, Shuguang, Kobler, James, Zeitels, Steven, Langer, Robert (2008) "Incorporation of a Matrix Metalloproteinase-Sensitive Substrate into Self-Assembling Peptides ¡V A Model for Biofunctional Scaffolds", Biomaterials, 29(11):1713-9.

Chau, Y., Langer, R.S. !¡±Polymer-linker-drug conjugates for targeted drug delivery!¡L 2003. U.S. Patent Application Serial no. 10/668,045

Chau, Y., Padera, R.F., Dang, N.M., Langer, R. !¡±In vivo anti-tumor efficacy of a novel polymer-peptide-drug conjugate sensitive to tumor-associated enzymes!¡L 2006. International Journal of Cancer 118(6): 1519-1526

Chau, Y., Dang, N.M., Tan, F.E., Langer, R. !¡±Biodistribution study with a novel dextran-peptide-methotrexate conjugate containing linkers cleavable by tumor-associated enzymes!¡L 2006. Journal of Pharmaceutical Sciences 95(3): 542-551

Chau, Y., Tan, F.E., Langer, R. !¡LSynthesis and characterization of dextran-peptide- methotrexate conjugates for tumor targeting via mediation by matrix-metalloproteinase II and matrix-metalloproteinase IX!¡L 2004. Bioconjugate Chemistry 15(4):931-941

Chau, Y., Luo, Y., Cheung, A.C.Y., Nagai, Y., Zhang, S., Kobler, J., Zeitels S.M. and Langer R. !¡±Incorporation of a Matrix Metalloproteinase-Sensitive Substrate into Self-Assembling Peptides !V A Model for Biofunctional Scaffolds!¡L 2007.